IOCB Most Significant Publications 2016

The most significant publications are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Mason, P. E.; Buttersack, T.; Bauerecker, S.; Jungwirth, P. A Non-Exploding Alkali Metal Drop on Water: From Blue Solvated Electrons to Bursting Molten Hydroxide. Angew. Chem. Int. Ed. 2016, 55, 13019-13022. https://doi.org/10.1002/anie.201605986
• Dziuba, D.; Jurkiewicz, P.; Cebecauer, M.; Hof, M.; Hocek, M. A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy. Angew. Chem. Int. Ed. 2016, 55, 174-178. https://doi.org/10.1002/anie.201507922
• Havlik, J.; Raabova, H.; Gulka, M.; Petrakova, V.; Krecmarova, M.; Masek, V.; Lousa, P.; Stursa, J.; Boyen, H.-G.; Nesladek, M.; Cigler, P. Benchtop Fluorination of Fluorescent Nanodiamonds on a Preparative Scale: Toward Unusually Hydrophilic Bright Particles. Adv. Funct. Mater. 2016, 26, 4134-4142. https://doi.org/10.1002/adfm.201504857
• Šebestík, J.; Kapitán, J.; Pačes, O.; Bouř, P. Diamagnetic Raman Optical Activity of Chlorine, Bromine, and Iodine Gases. Angew. Chem. Int. Ed. 2016, 55, 3504-3508. https://doi.org/10.1002/anie.201600058
• Rais, R.; Jančařík, A.; Tenora, L.; Nedelcovych, M.; Alt, J.; Englert, J.; Rojas, C.; Le, A.; Elgogary, A.; Tan, J.; Monincová, L.; Pate, K.; Adams, R.; Ferraris, D.; Powell, J.; Majer, P.; Slusher, B. S. Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma. J. Med. Chem. 2016, 59, 8621-8633. https://doi.org/10.1021/acs.jmedchem.6b01069
• Šácha, P.; Knedlík, T.; Schimer, J.; Tykvart, J.; Parolek, J.; Navrátil, V.; Dvořáková, P.; Sedlák, F.; Ulbrich, K.; Strohalm, J.; Majer, P.; Šubr, V.; Konvalinka, J. iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties. Angew. Chem. Int. Ed. 2016, 55, 2356-2360. https://doi.org/10.1002/anie.201508642
• Doležal, M.; Zábranský, A.; Dostál, J.; Vaněk, O.; Brynda, J.; Lepšík, M.; Hadravová, R.; Pichová, I. Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus. Retrovirology 2016, 13, 2. https://doi.org/10.1186/s12977-015-0235-8
• Slavikova, B.; Chodounska, H.; Nekardova, M.; Vyklicky, V.; Ladislav, M.; Hubalkova, P.; Krausova, B.; Vyklicky, L.; Kudova, E. Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene. J. Med. Chem. 2016, 59, 4724-4739. https://doi.org/10.1021/acs.jmedchem.6b00079
• Hnízda, A.; Škerlová, J.; Fábry, M.; Pachl, P.; Šinalová, M.; Vrzal, L.; Man, P.; Novák, P.; Řezáčová, P.; Veverka, V. Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia. BMC Biol. 2016, 14, 91. https://doi.org/10.1186/s12915-016-0313-y
• Hexnerová, R.; Křížková, K.; Fábry, M.; Sieglová, I.; Kedrová, K.; Collinsová, M.; Ullrichová, P.; Srb, P.; Williams, C.; Crump, M. P.; Tošner, Z.; Jiráček, J.; Veverka, V.; Žáková, L. Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain*. J. Biol. Chem. 2016, 291, 21234-21245. https://doi.org/10.1021/acs.orglett.6b01601
• Viková, J.; Collinsová, M.; Kletvíková, E.; Buděšínský, M.; Kaplan, V.; Žáková, L.; Veverka, V.; Hexnerová, R.; Aviñó, R. J. T.; Straková, J.; Selicharová, I.; Vaněk, V.; Wright, D. W.; Watson, C. J.; Turkenburg, J. P.; Brzozowski, A. M.; Jiráček, J. Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci. Rep. 2016, 6, 19431. https://doi.org/10.1038/srep19431
• Galeta, J.; Šála, M.; Dračínský, M.; Vrábel, M.; Havlas, Z.; Nencka, R. Single-Step Formation of Pyrimido[4,5-d]pyridazines by a Pyrimidine-Tetrazine Tandem Reaction. Org. Lett. 2016, 18, 3594-3597. https://doi.org/10.1021/acs.orglett.6b01601
• Machara, A.; Lux, V.; Kožíšek, M.; Grantz Šašková, K.; Štěpánek, O.; Kotora, M.; Parkan, K.; Pávová, M.; Glass, B.; Sehr, P.; Lewis, J.; Müller, B.; Kräusslich, H.-G.; Konvalinka, J. Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds. J. Med. Chem. 2016, 59, 545-558. https://doi.org/10.1021/acs.jmedchem.5b01089
• Klima, M.; Tóth, D. J.; Hexnerova, R.; Baumlova, A.; Chalupska, D.; Tykvart, J.; Rezabkova, L.; Sengupta, N.; Man, P.; Dubankova, A.; Humpolickova, J.; Nencka, R.; Veverka, V.; Balla, T.; Boura, E. Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein. Sci. Rep. 2016, 6, 23641. https://doi.org/10.1038/srep23641