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Light-Driven Radical Catch-and-Release with BODIPY Photocages
Chemical Science 2026: Early View
hotocages release payloads upon light irradiation and are widely used for spatiotemporal control in chemical biology and materials science. Although payload release is almost universally described as a heterolytic process, homolytic pathways that generate radicals can interfere and produce unintended off-target effects. If controlled, radical photorelease would open new avenues for applications such as polymerization, however the molecular factors that govern this process in photocages remain unknown. Here, we investigate how photophysics and payload identity influence heterolytic vs homolytic reactivity in BODIPY photocages. We find that high fluorescence quantum yields correlate with efficient homolytic cleavage, enabling reversible radical catch-and-release: light-assisted capture of radical payloads followed by clean photorelease under green light. This radical release can be suppressed by the introduction of iodide or boron-methyl substituents which promote intersystem crossing.…
Beyond traditional strain-promoted azide–alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides
Communications Chemistry 9: 171 (2026)
CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive Macrophages
Molecular Pharmaceutics 23 (5): 3114–3130 (2026)
Probing the Specificity of Fluorescent Deoxyribozymes Using Single-Step Selections and Machine Learning
ACS Chemical Biology 2026: Early View