IOCB Most Significant Publications 2017

The most significant publications are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Lubyova, B.; Hodek, J.; Zabransky, A.; Prouzova, H.; Hubalek, M.; Hirsch, I.; Weber, J. PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core. PLOS One 2017, 12, e0186982. https://doi.org/10.1371/journal.pone.0186982
• Navrátil, V.; Schimer, J.; Tykvart, J.; Knedlík, T.; Vik, V.; Majer, P.; Konvalinka, J.; Šácha, P. DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening. Nucleic Acids Res. 2017, 45, e10–e10. https://doi.org/10.1093/nar/gkw853
  
• Stetsovych, O.; Švec, M.; Vacek, J.; Chocholoušová, J. V.; Jančařík, A.; Rybáček, J.; Kosmider, K.; Stará, I. G.; Jelínek, P.; Starý, I. From helical to planar chirality by on-surface chemistry. Nat. Chem. 2017, 9, 213–218. https://doi.org/10.1038/nchem.2662
• Tichá, A.; Stanchev, S.; Vinothkumar, K. R.; Mikles, D. C.; Pachl, P.; Began, J.; Škerle, J.; Švehlová, K.; Nguyen, M. T. N.; Verhelst, S. H. L.; Johnson, D. C.; Bachovchin, D. A.; Lepšík, M.; Majer, P.; Strisovsky, K. General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem. Biol. 2017, 24, 1523–1536.e4. https://doi.org/10.1016/j.chembiol.2017.09.007
• Vázquez, A.; Dzijak, R.; Dračínský, M.; Rampmaier, R.; Siegl, S. J.; Vrabel, M. Mechanism-Based Fluorogenic trans-Cyclooctene–Tetrazine Cycloaddition. Angew. Chem. Int. Ed. 2017, 56, 1334–1337. https://doi.org/10.1002/anie.201610491
• Klima, M.; Chalupska, D.; Różycki, B.; Humpolickova, J.; Rezabkova, L.; Silhan, J.; Baumlova, A.; Dubankova, A.; Boura, E. Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein. Structure 2017, 25, 219–230. https://doi.org/10.1016/j.str.2016.11.021
• Rendler, T.; Neburkova, J.; Zemek, O.; Kotek, J.; Zappe, A.; Chu, Z.; Cigler, P.; Wrachtrup, J. Optical imaging of localized chemical events using programmable diamond quantum nanosensors. Nat. Commun. 2017, 8, 14701. https://doi.org/10.1038/ncomms14701
• Johnson, N.; Březinová, J.; Stephens, E.; Burbridge, E.; Freeman, M.; Adrain, C.; Strisovsky, K. Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis. Sci. Rep. 2017, 7, 7283. https://doi.org/10.1038/s41598-017-07556-3
• Mejdrová, I.; Chalupská, D.; Plačková, P.; Müller, C.; Šála, M.; Klíma, M.; Baumlová, A.; Hřebabecký, H.; Procházková, E.; Dejmek, M.; Strunin, D.; Weber, J.; Lee, G.; Matoušová, M.; Mertlíková-Kaiserová, H.; Ziebuhr, J.; Birkus, G.; Boura, E.; Nencka, R. Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. J. Med. Chem. 2017, 60, 100–118. https://doi.org/10.1021/acs.jmedchem.6b01465
• Tesei, G.; Vazdar, M.; Jensen, M. R.; Cragnell, C.; Mason, P. E.; Heyda, J.; Skepö, M.; Jungwirth, P.; Lund, M. Self-association of a highly charged arginine-rich cell-penetrating peptide. PNAS 2017, 114, 11428–11433. https://doi.org/10.1073/pnas.1712078114
• Kaleta, J.; Chen, J.; Bastien, G.; Dračínský, M.; Mašát, M.; Rogers, C. T.; Feringa, B. L.; Michl, J. Surface Inclusion of Unidirectional Molecular Motors in Hexagonal Tris(o-phenylene)cyclotriphosphazene. J. Am. Chem. Soc. 2017, 139, 10486–10498. https://doi.org/10.1021/jacs.7b05404
• Špaček, P.; Keough, D. T.; Chavchich, M.; Dračínský, M.; Janeba, Z.; Naesens, L.; Edstein, M. D.; Guddat, L. W.; Hocková, D. Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine–Guanine–(Xanthine) Phosphoribosyltransferase. J. Med. Chem. 2017, 60, 7539–7554. https://doi.org/10.1021/acs.jmedchem.7b00926
• Šebera, J.; Hattori, Y.; Sato, D.; Řeha, D.; Nencka, R.; Kohno, T.; Kojima, C.; Tanaka, Y.; Sychrovský, V. The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine. Nucleic Acids Res. 2017, 45, 5231–5242. https://doi.org/10.1093/nar/gkx157