Nejvýznamnější publikace 2017

Mezinárodní panel expertů a ředitel ÚOCHB každoročně vybírají nejvýznamnější publikace ÚOCHB.

Oceněné publikace jsou uvedeny v abecedním pořadí podle názvu.

• Lubyova, B.; Hodek, J.; Zabransky, A.; Prouzova, H.; Hubalek, M.; Hirsch, I.; Weber, J. PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core. PLOS One 2017, 12, e0186982. https://doi.org/10.1371/journal.pone.0186982
• Navrátil, V.; Schimer, J.; Tykvart, J.; Knedlík, T.; Vik, V.; Majer, P.; Konvalinka, J.; Šácha, P. DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening. Nucleic Acids Res. 2017, 45, e10–e10. https://doi.org/10.1093/nar/gkw853
• Stetsovych, O.; Švec, M.; Vacek, J.; Chocholoušová, J. V.; Jančařík, A.; Rybáček, J.; Kosmider, K.; Stará, I. G.; Jelínek, P.; Starý, I. From helical to planar chirality by on-surface chemistry. Nat. Chem. 2017, 9, 213–218. https://doi.org/10.1038/nchem.2662
• Tichá, A.; Stanchev, S.; Vinothkumar, K. R.; Mikles, D. C.; Pachl, P.; Began, J.; Škerle, J.; Švehlová, K.; Nguyen, M. T. N.; Verhelst, S. H. L.; Johnson, D. C.; Bachovchin, D. A.; Lepšík, M.; Majer, P.; Strisovsky, K. General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem. Biol. 2017, 24, 1523–1536.e4. https://doi.org/10.1016/j.chembiol.2017.09.007
• Vázquez, A.; Dzijak, R.; Dračínský, M.; Rampmaier, R.; Siegl, S. J.; Vrabel, M. Mechanism-Based Fluorogenic trans-Cyclooctene–Tetrazine Cycloaddition. Angew. Chem. Int. Ed. 2017, 56, 1334–1337. https://doi.org/10.1002/anie.201610491
• Klima, M.; Chalupska, D.; Różycki, B.; Humpolickova, J.; Rezabkova, L.; Silhan, J.; Baumlova, A.; Dubankova, A.; Boura, E. Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein. Structure 2017, 25, 219–230. https://doi.org/10.1016/j.str.2016.11.021
• Rendler, T.; Neburkova, J.; Zemek, O.; Kotek, J.; Zappe, A.; Chu, Z.; Cigler, P.; Wrachtrup, J. Optical imaging of localized chemical events using programmable diamond quantum nanosensors. Nat. Commun. 2017, 8, 14701. https://doi.org/10.1038/ncomms14701
• Johnson, N.; Březinová, J.; Stephens, E.; Burbridge, E.; Freeman, M.; Adrain, C.; Strisovsky, K. Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis. Sci. Rep. 2017, 7, 7283. https://doi.org/10.1038/s41598-017-07556-3
• Mejdrová, I.; Chalupská, D.; Plačková, P.; Müller, C.; Šála, M.; Klíma, M.; Baumlová, A.; Hřebabecký, H.; Procházková, E.; Dejmek, M.; Strunin, D.; Weber, J.; Lee, G.; Matoušová, M.; Mertlíková-Kaiserová, H.; Ziebuhr, J.; Birkus, G.; Boura, E.; Nencka, R. Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. J. Med. Chem. 2017, 60, 100–118. https://doi.org/10.1021/acs.jmedchem.6b01465
• Tesei, G.; Vazdar, M.; Jensen, M. R.; Cragnell, C.; Mason, P. E.; Heyda, J.; Skepö, M.; Jungwirth, P.; Lund, M. Self-association of a highly charged arginine-rich cell-penetrating peptide. PNAS 2017, 114, 11428–11433. https://doi.org/10.1073/pnas.1712078114
• Kaleta, J.; Chen, J.; Bastien, G.; Dračínský, M.; Mašát, M.; Rogers, C. T.; Feringa, B. L.; Michl, J. Surface Inclusion of Unidirectional Molecular Motors in Hexagonal Tris(o-phenylene)cyclotriphosphazene. J. Am. Chem. Soc. 2017, 139, 10486–10498. https://doi.org/10.1021/jacs.7b05404
• Špaček, P.; Keough, D. T.; Chavchich, M.; Dračínský, M.; Janeba, Z.; Naesens, L.; Edstein, M. D.; Guddat, L. W.; Hocková, D. Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine–Guanine–(Xanthine) Phosphoribosyltransferase. J. Med. Chem. 2017, 60, 7539–7554. https://doi.org/10.1021/acs.jmedchem.7b00926
• Šebera, J.; Hattori, Y.; Sato, D.; Řeha, D.; Nencka, R.; Kohno, T.; Kojima, C.; Tanaka, Y.; Sychrovský, V. The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine. Nucleic Acids Res. 2017, 45, 5231–5242. https://doi.org/10.1093/nar/gkx157