IOCB Most Significant Publications 2014

The most significant publications are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Jílková, A.; Horn, M.; Řezáčová, P.; Marešová, L.; Fajtová, P.; Brynda, J.; Vondrášek, J.; McKerrow, James H.; Caffrey, Conor R.; Mareš, M. Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch. Structure 2014, 22, 1786-1798. https://doi.org/10.1016/j.str.2014.09.015
• Šimák, O.; Pachl, P.; Fábry, M.; Buděšínský, M.; Jandušík, T.; Hnízda, A.; Skleničková, R.; Petrová, M.; Veverka, V.; Řezáčová, P.; Brynda, J.; Rosenberg, I. Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidases. Org. Biomol. Chem. 2014, 12, 7971-7982. http://dx.doi.org/10.1039/C4OB01332H
• Buděšínský, M.; Vaněk, V.; Dračínský, M.; Pohl, R.; Poštová-Slavětínská, L.; Sychrovský, V.; Pícha, J.; Císařová, I. Determination of the configuration in six-membered saturated heterocycles (N, P, S, Se) and their oxidation products using experimental and calculated NMR chemical shifts. Tetrahedron 2014, 70, 3871-3886. https://doi.org/10.1016/j.tet.2014.04.047
• Opekar, S.; Pohl, R.; Beran, P.; Rulíšek, L.; Beier, P. Diethyl Fluoronitromethylphosphonate: Synthesis and Application in Nucleophilic Fluoroalkyl Additions. Chem. Eur. J. 2014, 20, 1453-1458. https://doi.org/10.1002/chem.201303817
• Savolainen, J.; Uhlig, F.; Ahmed, S.; Hamm, P.; Jungwirth, P. Direct observation of the collapse of the delocalized excess electron in water. Nat. Chem. 2014, 6, 697-701. https://doi.org/10.1038/nchem.1995
• Rehor, I.; Mackova, H.; Filippov, S. K.; Kucka, J.; Proks, V.; Slegerova, J.; Turner, S.; Van Tendeloo, G.; Ledvina, M.; Hruby, M.; Cigler, P. Fluorescent Nanodiamonds with Bioorthogonally Reactive Protein-Resistant Polymeric Coatings. ChemPlusChem 2014, 79, 21-24. https://doi.org/10.1002/cplu.201300339
• Pospíšil, L.; Bednárová, L.; Štěpánek, P.; Slavíček, P.; Vávra, J.; Hromadová, M.; Dlouhá, H.; Tarábek, J.; Teplý, F. Intense Chiroptical Switching in a Dicationic Helicene-Like Derivative: Exploration of a Viologen-Type Redox Manifold of a Non-Racemic Helquat. J. Am. Chem. Soc. 2014, 136, 10826-10829. https://doi.org/10.1021/ja500220j
• Krečmerová, M.; Pohl, R.; Masojídková, M.; Balzarini, J.; Snoeck, R.; Andrei, G. N4-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity. Bioorg. Med. Chem. 2014, 22, 2896-2906. https://doi.org/10.1016/j.bmc.2014.03.031
• Šebestík, J.; Bouř, P. Observation of Paramagnetic Raman Optical Activity of Nitrogen Dioxide. Angew. Chem. Int. Edit. 2014, 53, 9236-9239. https://doi.org/10.1002/anie.201403887
• Kafka, F.; Holan, M.; Hidasová, D.; Pohl, R.; Císařová, I.; Klepetářová, B.; Jahn, U. Oxidative Catalysis Using the Stoichiometric Oxidant as a Reagent: An Efficient Strategy for Single-Electron-Transfer-Induced Tandem Anion–Radical Reactions. Angew. Chem. Int. Edit. 2014, 53, 9944-9948. https://doi.org/10.1002/anie.201403776
• Vaníková, Z.; Hocek, M. Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases. Angew. Chem. Int. Edit. 2014, 53, 6734-6737. https://doi.org/10.1002/anie.201402370
• Chalupský, J.; Rokob, T. A.; Kurashige, Y.; Yanai, T.; Solomon, E. I.; Rulíšek, L.; Srnec, M. Reactivity of the Binuclear Non-Heme Iron Active Site of Δ9 Desaturase Studied by Large-Scale Multireference Ab Initio Calculations. J. Am. Chem. Soc. 2014, 136, 15977-15991. https://doi.org/10.1021/ja506934k
• Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; Zábranská, H.; Pohl, R.; Konečný, P.; Džubák, P.; Votruba, I.; Hajdúch, M.; Řezáčová, P.; Veverka, V.; Hocek, M.; Pichová, I. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. J. Med. Chem. 2014, 57, 8268-8279. https://doi.org/10.1021/jm500497v
• Růžička, M.; Čížková, M.; Jirásek, M.; Teplý, F.; Koval, D.; Kašička, V. Study of deoxyribonucleic acid–ligand interactions by partial filling affinity capillary electrophoresis. J. Chromatogr. A 2014, 1349, 116-121. https://doi.org/10.1016/j.chroma.2014.04.061
• Zoll, S.; Stanchev, S.; Began, J.; Škerle, J.; Lepšík, M.; Peclinovská, L.; Majer, P.; Strisovsky, K. Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures. EMBO J. 2014, 33, 2408-2421. https://doi.org/10.15252/embj.201489367
• Baumlova, A.; Chalupska, D.; Róźycki, B.; Jovic, M.; Wisniewski, E.; Klima, M.; Dubankova, A.; Kloer, D. P.; Nencka, R.; Balla, T.; Boura, E. The crystal structure of the phosphatidylinositol 4-kinase IIα. EMBO Rep. 2014, 15, 1085-1092. https://doi.org/10.15252/embr.201438841
• Kožíšek, M.; Lepšík, M.; Grantz Šašková, K.; Brynda, J.; Konvalinka, J.; Řezáčová, P. Thermodynamic and structural analysis of HIV protease resistance to darunavir – analysis of heavily mutated patient-derived HIV-1 proteases. FEBS J. 2014, 281, 1834-1847. https://doi.org/10.1111/febs.12743
• Čermáková, K.; Tesina, P.; Demeulemeester, J.; El Ashkar, S.; Méreau, H.; Schwaller, J.; Řezáčová, P.; Veverka, V.; De Rijck, J. Validation and Structural Characterization of the LEDGF/p75–MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia. Cancer Res. 2014, 74, 5139-5151. https://doi.org/10.1158/0008-5472.CAN-13-3602
• Vazdar, K.; Kunetskiy, R.; Saame, J.; Kaupmees, K.; Leito, I.; Jahn, U. Very Strong Organosuperbases Formed by Combining Imidazole and Guanidine Bases: Synthesis, Structure, and Basicity. Angew. Chem. Int. Edit. 2014, 53, 1435-1438. https://doi.org/10.1002/anie.201307212