Nejvýznamnější publikace 2014

Mezinárodní panel expertů a ředitel ÚOCHB každoročně vybírají nejvýznamnější publikace ÚOCHB.

Oceněné publikace jsou uvedeny v abecedním pořadí podle názvu.

• Jílková, A.; Horn, M.; Řezáčová, P.; Marešová, L.; Fajtová, P.; Brynda, J.; Vondrášek, J.; McKerrow, James H.; Caffrey, Conor R.; Mareš, M. Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch. Structure 2014, 22, 1786-1798. https://doi.org/10.1016/j.str.2014.09.015
• Šimák, O.; Pachl, P.; Fábry, M.; Buděšínský, M.; Jandušík, T.; Hnízda, A.; Skleničková, R.; Petrová, M.; Veverka, V.; Řezáčová, P.; Brynda, J.; Rosenberg, I. Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidases. Org. Biomol. Chem. 2014, 12, 7971-7982. http://dx.doi.org/10.1039/C4OB01332H
• Buděšínský, M.; Vaněk, V.; Dračínský, M.; Pohl, R.; Poštová-Slavětínská, L.; Sychrovský, V.; Pícha, J.; Císařová, I. Determination of the configuration in six-membered saturated heterocycles (N, P, S, Se) and their oxidation products using experimental and calculated NMR chemical shifts. Tetrahedron 2014, 70, 3871-3886. https://doi.org/10.1016/j.tet.2014.04.047
• Opekar, S.; Pohl, R.; Beran, P.; Rulíšek, L.; Beier, P. Diethyl Fluoronitromethylphosphonate: Synthesis and Application in Nucleophilic Fluoroalkyl Additions. Chem. Eur. J. 2014, 20, 1453-1458. https://doi.org/10.1002/chem.201303817
• Savolainen, J.; Uhlig, F.; Ahmed, S.; Hamm, P.; Jungwirth, P. Direct observation of the collapse of the delocalized excess electron in water. Nat. Chem. 2014, 6, 697-701. https://doi.org/10.1038/nchem.1995
• Rehor, I.; Mackova, H.; Filippov, S. K.; Kucka, J.; Proks, V.; Slegerova, J.; Turner, S.; Van Tendeloo, G.; Ledvina, M.; Hruby, M.; Cigler, P. Fluorescent Nanodiamonds with Bioorthogonally Reactive Protein-Resistant Polymeric Coatings. ChemPlusChem 2014, 79, 21-24. https://doi.org/10.1002/cplu.201300339
• Pospíšil, L.; Bednárová, L.; Štěpánek, P.; Slavíček, P.; Vávra, J.; Hromadová, M.; Dlouhá, H.; Tarábek, J.; Teplý, F. Intense Chiroptical Switching in a Dicationic Helicene-Like Derivative: Exploration of a Viologen-Type Redox Manifold of a Non-Racemic Helquat. J. Am. Chem. Soc. 2014, 136, 10826-10829. https://doi.org/10.1021/ja500220j
• Krečmerová, M.; Pohl, R.; Masojídková, M.; Balzarini, J.; Snoeck, R.; Andrei, G. N4-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity. Bioorg. Med. Chem. 2014, 22, 2896-2906. https://doi.org/10.1016/j.bmc.2014.03.031
• Šebestík, J.; Bouř, P. Observation of Paramagnetic Raman Optical Activity of Nitrogen Dioxide. Angew. Chem. Int. Edit. 2014, 53, 9236-9239. https://doi.org/10.1002/anie.201403887
• Kafka, F.; Holan, M.; Hidasová, D.; Pohl, R.; Císařová, I.; Klepetářová, B.; Jahn, U. Oxidative Catalysis Using the Stoichiometric Oxidant as a Reagent: An Efficient Strategy for Single-Electron-Transfer-Induced Tandem Anion–Radical Reactions. Angew. Chem. Int. Edit. 2014, 53, 9944-9948. https://doi.org/10.1002/anie.201403776
• Vaníková, Z.; Hocek, M. Polymerase Synthesis of Photocaged DNA Resistant against Cleavage by Restriction Endonucleases. Angew. Chem. Int. Edit. 2014, 53, 6734-6737. https://doi.org/10.1002/anie.201402370
• Chalupský, J.; Rokob, T. A.; Kurashige, Y.; Yanai, T.; Solomon, E. I.; Rulíšek, L.; Srnec, M. Reactivity of the Binuclear Non-Heme Iron Active Site of Δ9 Desaturase Studied by Large-Scale Multireference Ab Initio Calculations. J. Am. Chem. Soc. 2014, 136, 15977-15991. https://doi.org/10.1021/ja506934k
• Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; Zábranská, H.; Pohl, R.; Konečný, P.; Džubák, P.; Votruba, I.; Hajdúch, M.; Řezáčová, P.; Veverka, V.; Hocek, M.; Pichová, I. Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides. J. Med. Chem. 2014, 57, 8268-8279. https://doi.org/10.1021/jm500497v
• Růžička, M.; Čížková, M.; Jirásek, M.; Teplý, F.; Koval, D.; Kašička, V. Study of deoxyribonucleic acid–ligand interactions by partial filling affinity capillary electrophoresis. J. Chromatogr. A 2014, 1349, 116-121. https://doi.org/10.1016/j.chroma.2014.04.061
• Zoll, S.; Stanchev, S.; Began, J.; Škerle, J.; Lepšík, M.; Peclinovská, L.; Majer, P.; Strisovsky, K. Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures. EMBO J. 2014, 33, 2408-2421. https://doi.org/10.15252/embj.201489367
• Baumlova, A.; Chalupska, D.; Róźycki, B.; Jovic, M.; Wisniewski, E.; Klima, M.; Dubankova, A.; Kloer, D. P.; Nencka, R.; Balla, T.; Boura, E. The crystal structure of the phosphatidylinositol 4-kinase IIα. EMBO Rep. 2014, 15, 1085-1092. https://doi.org/10.15252/embr.201438841
• Kožíšek, M.; Lepšík, M.; Grantz Šašková, K.; Brynda, J.; Konvalinka, J.; Řezáčová, P. Thermodynamic and structural analysis of HIV protease resistance to darunavir – analysis of heavily mutated patient-derived HIV-1 proteases. FEBS J. 2014, 281, 1834-1847. https://doi.org/10.1111/febs.12743
• Čermáková, K.; Tesina, P.; Demeulemeester, J.; El Ashkar, S.; Méreau, H.; Schwaller, J.; Řezáčová, P.; Veverka, V.; De Rijck, J. Validation and Structural Characterization of the LEDGF/p75–MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia. Cancer Res. 2014, 74, 5139-5151. https://doi.org/10.1158/0008-5472.CAN-13-3602
• Vazdar, K.; Kunetskiy, R.; Saame, J.; Kaupmees, K.; Leito, I.; Jahn, U. Very Strong Organosuperbases Formed by Combining Imidazole and Guanidine Bases: Synthesis, Structure, and Basicity. Angew. Chem. Int. Edit. 2014, 53, 1435-1438. https://doi.org/10.1002/anie.201307212