Projects co-financed by NRP through TACR

The TRIPLE project is co-financed with the state support of the Technology Agency of the Czech Republic as part of the National Recovery Plan from the European Recovery and Resilience Facility.

Registration number: TH90010001

Fundamental life science and practical medicine need tools to probe electromagnetic field, temperature, and pH with nanometer spatial resolution in order to gain insights into the intra- and extra-cellular processes. EXTRASENS develops multimodal quantum biosensor complemented with super-resolution bioimaging functionality using nitrogen-vacancy (NV) and silicon-vacancy (SiV) color centers in biocompatible diamond single crystal nanoneedles (DNNs) validated in the lab (TRL4). Key Performance Indicators require spatial resolution of the real-time measurements of electric and magnetic fields, temperature and pH to be less than 20 nm achievable due to perfect DNN crystallinity and precise positioning of color centers over the needle axis. The benchmark for the multimodal sensing is determined by exceptional sensitivity of color center optical properties to tiny changes of probed physical values, that has already been demonstrated by project partners and/or other groups. By converting quantum science concepts into technological applications, EXTRASENS develops new exploitable products (all to TRL4):

• diamond nanoneedles with precisely positioned NV and SiV color centers, synthesized using scalable chemical vapor deposition (CVD),
• routines and methodologies for bio-functionalization of CVD diamonds,
• multimodal sensor based on NV and SiV, or only NV color centers in DNNs,
• methods, algorithms, and software applicable for various super-resolution imaging schemes complemented with quantum sensing,
• bioimaging device with spatial resolution < 20 nm.

Realization schedule: 1. 5. 2024 – 31. 12. 2026

Beneficiary: IOCB Prague

Principal investigator: Petr Cígler (the team will work on the synthesis of diamond nanoneedles and their biocompatibility)

Project partners:

• University of Eastern (Finland), Center of Photonics Research, Prof. Polina Kuzhir – Project Coordinator
• Ulm University (Germany), Institute for Quantum Optics, Prof. Fedor Jelezko
• Center for Physical Sciences and Technology (Lithuania), Department of Molecular Compound Physics, Prof. Leonas Valkunas
• University of Warsaw (Poland), Quantum Optics Lab, Dr. Radek Łapkiewicz

The EXTRASENS project is co-financed with the state support of the Technology Agency of the Czech Republic as part of the QuantERA II Call 2023 and The Program for the Support of Applied Research and Experimental Development EPSILON. The EXTRASENS project is financed as part of the National Recovery Plan from the European Recovery and Resilience Facility.

Registration number: TH86010003

TRIPLE will bring existing and future RDF resources to a broader group of researchers by developing innovative solutions on four fronts:

• We will store private (unpublished) data in Solid Pods, an emerging technology enabling decentralized private vaults to host private RDF endpoints, execute federated SPARQL queries, and cache data and results.
• We will optimise federated queries spanning public and private SPARQL endpoints allowing users to query multiple resources from within their Solid Pod.
• We will adapt state-of-the-art RDF documentation tools and make them available for all SPARQL endpoints, including Solid Pods.
• We will develop data model visualization, sets of standardized federated queries, and advanced query analysis and evaluation tools to help new users understand the data sources and run efficient federated queries. Finally, a demonstrator will show the impact of these advances when applied to a technically challenging use case of scientific relevance: the search for suitable organisms for bioremediation.

Planned results of the project (IOCB):

• Federated Query Analyser (R) as a federated query evaluation analysis tool that allows to monitor all communication between query evaluation endpoints.
• Federated Query Engine (R) as an extension of the existing SPARQL engine implementation with advanced capabilities for evaluating federated SPARQL queries.

Realization schedule: 1. 10. 2023 – 30. 9. 2025

Beneficiary: IOCB Prague

Principal investigator: RNDr. Jakub Galgonek, Ph.D.

Project partners:

• SIB Swiss Institute of Bioinformatics
• Universiteit Gent

The TRIPLE project is co-financed with the state support of the Technology Agency of the Czech Republic as part of the CHIST-ERA IV Call Open Research Data2022 and The Program for the Support of Applied Research and Experimental Development EPSILON. The TRIPLE project is financed as part of the National Recovery Plan from the European Recovery and Resilience Facility.