Bioorthogonal reactions are routinely employed chemical transformations that can be performed in living systems without interfering with natural processes or harming the organism. Scientists from Milan Vrábel research group at IOCB Prague wrote a review article with examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular organelles.
Organelle-targeted bioorthogonal reactions have the potential to significantly advance our understanding of cellular organization and function, provide new pathways for basic research and clinical applications, and shape the direction of cell biology and medical research.
Read the review: Šlachtová, V.; Chovanec, M.; Rahm, M.; Vrabel, M. Bioorthogonal Chemistry in Cellular Organelles. Top. Curr. Chem. (Z) 382, 2, 2024. https://doi.org/10.1007/s41061-023-00446-5
