COVER: Cobalt bis(dicarbollide) alkylsulfonamides inhibit tumor-specific carbonic anhydrase IX
27 December 2020
The ChemPlusChem front cover shows cobalt bis(dicarbollide) alkylsulfonamide, which acts as an inhibitor of carbonic anhydrase IX (CA IX). This enzyme is overexpressed on the cell surface of hypoxic cancer cells and plays a critical role in cancer cell survival and the formation of metastases. The inhibition of CA IX is known to result in reduced tumor growth.
The new family of potent and selective CA IX inhibitors prepared and analyzed by the teams led by Bohumír Grüner from the Institute of Inorganic Chemistry of the CAS and Pavlína Řezáčová from IOCB Prague combines a structural motif of a bulky inorganic cobalt bis(dicarbollide) polyhedral ion with a propylsulfonamido anchor group.
Read the paper:
- Grüner, B.; Kugler, M.; El Anwar, S.; Holub, J.; Nekvinda, J.; Bavol, D.; Růžičková, Z.; Pospíšilová, K.; Fábry, M.; Král, V.; Brynda, J.; Řezáčová, P. Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX. ChemPlusChem 2020. https://doi.org/10.1002/cplu.202000574
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