Invited Lecture – Venki Ramakrishnan

15 April 2019
IOCB Prague
Invited Lecture – Venki Ramakrishnan
Speaker

Prof. Venki Ramakrishnan (MRC Laboratory of Molecular Biology, Cambridge, UK)

Topic

Termination of Translation in Bacteria and Eukaryotes

Date and time

15 April 2019, 10 p.m.

Place

IOCB Prague, Lecture Hall (Building A, 2nd floor, A2.01)

Abstract

Termination of translation in all domains of life is triggered by the entry of a stop codon in the A site of the ribosome. These three codons are recognized by a protein release factor. However, release factors in bacteria and eukaryotes appear to have no structural or sequence similarity. In this talk, I will describe structural work that sheds the basis of release factor function in the two domains of life and show that despite their dissimilarity, they share certain common features.

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