Rational design and characterization of inhibitors targeting influenza polymerase
Hejdánek et al. Antivir Res 2021; Gregor et al. Molecules 2021; Zima et al. Eur J Med Chem 2020
Rational design and characterization of inhibitors targeting influenza neuraminidase
Zima et al. Bioorg Med Chem 2019; Pokorná et al. Viruses 2018; Berenguer Albiñana et al. Eur J Med Chem 2016
Ultrasensitive microcalorimetry in the study of biomolecular interactions and protein stability
Vavřina et al. Biochemistry 2021; Rulíšek et al. Angew Chem Int Ed 2021; Began et al. EMBO J 2020; Heyda et al. J Phys Chem B 2011; Vaněk et al. J Med Chem 2009; Řezáčová et al. Mol Microbiol 2008; Král et al. Proteins 2008; Kožíšek et al. Eur J Biochem 2008; Vondrášek et al. Chem Eur J 2007
Protein-protein and protein-ligand interaction techniques (HTS, AlphaScreen, SPR, ITC, DSC)
Kožíšek et al. Biochem J 2018; Trempe et al. Sci Rep 2016; Sivá et al. Sci Rep 2016; Németh et al. J Inorg Biochem 2015; Rozbeský et al. Int J Mol Sci 2014; Németh et al. Protein Sci 2014; Németh et al. J Biol Inorg Chem 2014; Motáčková et al. Biomol NMR Assign 2009
Viral resistance development in HIV positive patiens treated with inhibitors of HIV protease
Kožíšek et al. FEBS J 2014; Grantz Šašková et al. J Virol 2014; Schimer et al. J Med Chem 2012; Kožíšek et al. Antimicrob Agents Chemother 2012; Grantz Šašková et al. J Virol 2009; Grantz Šašková et al. Protein Sci 2008; Bartoňová et al. Antivir Res 2008; Kožíšek et al. J Mol Biol 2007
Rational design and characterization of HIV protease inhibitors based on metallacarboranes
Řezáčová et al. J Med Chem 2009; Kožíšek et al. J Med Chem 2008; Kubát et al. J Phys Chem B 2007; Cígler and Kožíšek et al. Proc Natl Acad Sci USA 2005
Research of the insertions in HIV protease
Kožíšek et al. J Virol 2008
HIV capsid and viral assembly
Machara et al. J Med Chem 2016; Kožíšek et al. Bioorg Med Chem Lett 2016; Doležal et al. J Biol Chem 2016
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