Profile

Positions


2022 Associate Professor in Genetics, Molecular Biology and Virology, Charles University, Faculty of Science, Prague, Czech Republic
2018 Assistant Professor, Charles University, Faculty of Science, Prague, Czech Republic
since 2018Head of the Laboratory of Structural Biology of Transcription Regulation, Charles University, Faculty of Science, Department of Cell Biology, Prague, Czech Republic
since 2012Senior PI, IOCB Prague, Structural Biology, Program leader for Biomolecular NMR
2009-2012Industrial research fellow, University of Leicester, United Kingdom
2003-2009Postdoctoral fellow, University of Leicester, United Kingdom


Selected papers

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
Nature Communications 6: 7968 (2015)
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers
Nature Structural & Molecular Biology 25 (1): 61-72 (2018)
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
Proceedings of the National Academy of Sciences of the United States of America 115 (30): E7053-E7062 (2018)

Latest publications

NMR screen reveals the diverse structural landscape of a G-quadruplex library
Chemistry - A European Journal 2024: Early View
Aurora: a fluorescent deoxyribozyme for high-throughput screening
Nucleic Acids Research 52 (15): 9049–9061 (2024)
Apollon: a deoxyribozyme that generates a yellow product
Nucleic Acids Research 52 (15): 9062–9075 (2024)