P JAC projects

Programme Johannes Amos Comenius is a thematic operational program for the period of 2021-2027 under the Ministry of Education, Youth and Sports. IOCB received financial support for the following projects.

Registration number: CZ.02.01.01/00/22_008/0004575

Brief description: The project aims to develop a Czech-driven research and innovation ecosystem in the field of RNA medicine and expand therapeutic potential of RNA, which emerged in recent years as a remarkable therapeutic tool for personalized medicine and immunotherapy, as well as to address genetic, infectious, and chronic diseases linked to RNA metabolism. The project combines cutting-edge research on key molecular mechanisms in RNA biology and the translation of the knowledge into practical applications.

Realization schedule: 1. 1. 2024 – 31. 10. 2028

Beneficiary: IOCB Prague

Principal investigator: Prof. Ing. Michal Hocek, CSc. DSc.

Project partners:

• Institute of Molecular Genetics of the CAS
• Masaryk University (CEITEC)
• Biology Centre of the CAS
• Institute of Microbiology of the CAS
• Charles University, Faculty of Science

Project homepage: www.uochb.cz/en/rna4t

Registration number: CZ.02.01.01/00/23_015/0008210

Brief description: The project aims to renew and further develop the ELIXIR CZ infrastructure to address current life sciences challenges in strategic thematic areas through five key activities that will have a positive impact on infrastructure users and the wider research community.

Realization schedule: 1. 3. 2024 – 31. 12. 2026

Beneficiary: IOCB Prague

Principal investigator: Prof. RNDr. Jiří Vondrášek, CSc.

Project partners:

• CESNET z.s.p.o.
• Masaryk University

Project homepage: www.elixir-czech.cz

Registration number: CZ.02.01.01/00/22_008/0004558

Brief description: The AMULET project focuses on advanced engineering of multiscale materials from sub-nanometer design to integration into functional architectures for use in numerous applications in electrical, medical and environmental technologies, including socio-economic impact assessment. These are Key Enabling Technologies (KETs), which are essential for EU competitiveness. Interdisciplinary excellent research will be carried out by a team composed of top-level scientists and will benefit from extensive international synergies.

Realization schedule: 1. 1. 2024 – 30. 6. 2028

Beneficiary: J. Heyrovský Institute of Physical Chemistry of the CAS

Project partners:

• IOCB Prague (PI: Petr Cígler, Ph.D.)
• University of Chemistry and Technology, Prague
• Jan Evangelista Purkyně University in Ústí nad Labem
• Institute of Photonics and Electronics of the CAS
• Charles University
• Nuclear Physics Institute of the CAS
• Institute of Physics of the CAS

Project homepage: www.projekt-amulet.cz

Registration number: CZ.02.01.01/00/22_008/0004607

Brief description: The project synergistically links major basic and translational research institutions and multidisciplinary teams using modern pharmaceutical science approaches with strong application potential. The aim of the project is excellent research and development of advanced therapeutics, (nano)formulations, and drug delivery systems, using innovative technologies, the latest approaches, and experimental models of translational drug development within the network of excellent R&D centers.

Realization schedule: 1. 3. 2024 – 29. 2. 2028

Beneficiary: Charles University, Faculty of Pharmacy in Hradec Králové & Faculty of Medicine in Hradec Králové

Project partners:

• IOCB Prague (PIs: Radim Nenecka, Ph.D., Evžen Bouřa, Ph.D., Milan Vrábel, Ph.D.)
• University of Chemistry and Technology, Prague
• Institute of Macromolecular Chemistry of the CAS
• Masaryk University (CEITEC)

Project homepage: www.faf.cuni.cz/NETPHARM

Registration number: CZ.02.01.01/00/22_010/0008923

Brief description: The project focuses on implementing a research proposal in the field of cancer treatment, which received a high evaluation in the Horizon-MSCA-2023-PF call but was not selected for funding. The author of the proposal, titled "Uncovering the Role of Epigenetics in LACTB’s Tumor Suppressive Landscape", is Gabriel Miguel Rodríguez Goméz from the Zuzana Kečkéšová Group. In addition to generating new scientific knowledge and transferring know-how from abroad, the aim is to strengthen international collaboration and support the institute’s international environment.

Realization schedule: 1. 1. 2025–31. 12. 2026

Principal investigator: Mgr. Zuzana Kečkéšová, Ph.D.

Beneficiary: Institute of Organic Chemistry and Biochemistry of the CAS

Registration number: CZ.02.01.01/00/22_010/0008123

Brief description: The project focuses on implementing a research proposal in the field of cancer treatment, which received a high evaluation in the Horizon-MSCA-2023-PF call but was not selected for funding. The author of the proposal, titled "Identification and characterization of posttranslational modifications (PTMs) of LACTB for its implications in cancer", is Chung Weng Phang from the Zuzana Kečkéšová Group. In addition to generating new scientific knowledge and transferring know-how from abroad, the aim is to strengthen international collaboration and support the institute’s international environment.

Realization schedule: 1. 1. 2024–31. 12. 2025

Principal investigator: Mgr. Zuzana Kečkéšová, Ph.D.

Beneficiary: Institute of Organic Chemistry and Biochemistry of the CAS

Registration number: CZ.02.01.01/00/22_010/0002733

Brief description: The project is focused on the implementation of a research proposal in the field of biochemistry of plant specialized metabolites, that achieved a high score within the Horizon-MSCA-2021-PF call but could not be funded. The 2-year research is carried out by a foreign researcher at IOCB under the guidance of a leading scientist of the institute. The purpose of the project is to fulfil research goals primarily, but also the support of foreign cooperation, the transfer of experience and knowledge and the development of the career of a young researcher with a connection to the Czech scientific environment.

Realization schedule: 1. 5. 2023–31. 5. 2025

Principal investigator: Mgr. Tomáš Pluskal, Ph.D.

Beneficiary: IOCB Prague