Proteases of human viruses: properties, maturation, inhibition
Proteases of Human Pathogens
Abstract
Viral proteases are crucial for successful viral replication. We will elucidate the details of their proteolytic autoactivation and search for protease-specific inhibitors. Our focus will mainly be on proteases from flaviviruses (Zika, Dengue), coronaviruses (SARS-CoV-2), and retroviruses (HIV).
The project involves designing mutated protein variants, cloning, protein expression, and purification, along with screening compound libraries. These steps will be followed by biophysical characterization and crystallization. Additionally, we will focus on developing and adapting cell-based phenotypic assays and designing light-activatable protease variants.
This work seeks to contribute to opening new paths to potentially innovative therapies.
Field of study: Biochemistry
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
University partners
How to apply
Contact: tatana.majerova@uochb.cas.cz