The group of Petr Beier at IOCB Prague has recently introduced difluoromethyl azide (Eur. J. Org. Chem. 2018, 5087).
This article has appeared in the special issue of European Journal of Organic Chemistry featuring the Institute of Organic Chemistry and Biochemistry. Together with trifluoromethyl azide developed in Beier’s group earlier (Angew. Chem. Int. Ed. 2017, 56, 346) they constitute a useful set of fluorinated azides with application in synthesis (regioselective formation of N-fluoroalkylated 1,2,3-triazoles).
Thanks to the collaboration of IOCB and CF Plus Chemicals (a spin-off of the ETH Zurich located in Brno, Czech Republic), new fluoroalkyl azides are now commercially available as safe and easily handled solutions.
The chemistry of these N-fluoroalkyl heterocycles was recently expanded to a variety of previously unreported imidazoles and pyrroles, which are potentially useful in drug discovery programmes employing rhodium carbene chemistry (Chem. Commun. 2018, 54, 3258).
Thanks to the collaboration of IOCB and CF Plus Chemicals (a spin-off of the ETH Zurich located in Brno, Czech Republic), new fluoroalkyl azides are now commercially available as safe and easily handled solutions.
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