Helena Raabová from Petr Cígler Group from IOCB Prague together with David Chvátil from the Nuclear Physics Institute of the CAS has prepared a highly photostable fluorescent nanosensor. The nano-optode consists of a fluorescent nanodiamond core coated with a responsive copolymer.
This macromolecular "signal transducer" swells and shrinks according to both pH and temperature in the physiologically relevant ranges. Actuation of the polymer modulates fluorescence properties of the core nanodiamond, allowing simple optical imaging of pH and temperature.
The nano-optode has application potential in non-perturbing biosensing.
Read the paper:
- Raabova, H.; Chvatil, D.; Cigler, P. Diamond nano-optode for fluorescent measurements of pH and temperature. Nanoscale 2019, 11, 18537-18542. https://doi.org/10.1039/C9NR03710A
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