RNA viruses and their big health threat are nowadays world-wide known especially because of the SARS-CoV-2 pandemic. Michal Hocek lab in collaboration with several other groups at IOCB Prague has recently published in ACS Infectious Diseases an article dealing with base-modified 7-deazaadenine ribonucleosides possessing an antiviral activity against selected RNA viruses, including Zika (Flaviviridae) and SARS-CoV-2 (Coronaviridae).
The mode of action of these compounds is through the inhibition of the viral RNA-dependent RNA polymerase. The published research discusses the laborious synthesis, the in vitro inhibition studies together with the metabolism and toxicity studies using human liver cell lines.
Read the paper:
- Milisavljevic, N.; Konkolová, E.; Kozák, J.; Hodek, J.; Veselovská, L.; Sýkorová, V.; Čížek, K.; Pohl, R.; Eyer, L.; Svoboda, P.; Růžek, D.; Weber, J.; Nencka, R.; Bouřa, E.; Hocek, M., Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses. ACS Infectious Diseases 2021. https://doi.org/10.1021/acsinfecdis.0c00829
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