IOCB Most Significant Publications 2020

The most significant publications in CHEM, BIO & PHYS clusters are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Šála, M.; Hollinger, K. R.; Thomas, A. G.; Dash, R. P.; Tallon, C.; Veeravalli, V.; Lovell, L.; Kögler, M.; Hřebabecký, H.; Procházková, E.; Nešuta, O.; Donoghue, A.; Lam, J.; Rais, R.; Rojas, C.; Slusher, B. S.; Nencka, R. Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Disease. J. Med. Chem. 2020, 63, 6028–6056. http://dx.doi.org/10.1021/acs.jmedchem.0c00278
• Čechová, L.; Filo, J.; Dračínský, M.; Slavov, C.; Sun, D.; Janeba, Z.; Slanina, T.; Wachtveitl, J.; Procházková, E.; Cigáň, M. Polysubstituted 5-Phenylazopyrimidines: Extremely Fast Non-ionic Photochromic Oscillators. Angew. Chem. Int. Ed. 2020, 59, 15590–15594. http://dx.doi.org/10.1002/anie.202007065
• Santos Hurtado, C.; Bastien, G.; Mašát, M.; Štoček, J. R.; Dračínský, M.; Rončević, I.; Císařová, I.; Rogers, C. T.; Kaleta, J. Regular Two-Dimensional Arrays of Surface-Mounted Molecular Switches: Switching Monitored by UV–vis and NMR Spectroscopy. J. Am. Chem. Soc. 2020, 142, 9337–9351. http://dx.doi.org/10.1021/jacs.0c01753
• Galeta, J.; Dzijak, R.; Obořil, J.; Dračínský, M.; Vrabel, M. A Systematic Study of Coumarin–Tetrazine Light-Up Probes for Bioorthogonal Fluorescence Imaging. Chem. Eur. J. 2020, 26, 9945–9953. http://dx.doi.org/10.1002/chem.202001290
• Zima, V.; Radilová, K.; Kožíšek, M.; Albiñana, C. B.; Karlukova, E.; Brynda, J.; Fanfrlík, J.; Flieger, M.; Hodek, J.; Weber, J.; Majer, P.; Konvalinka, J.; Machara, A. Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. Eur. J. Med. Chem. 2020, 208, 112754. http://dx.doi.org/10.1016/j.ejmech.2020.112754

• Houštecká, R.; Hadzima, M.; Fanfrlík, J.; Brynda, J.; Pallová, L.; Hánová, I.; Mertlíková-Kaiserová, H.; Lepšík, M.; Horn, M.; Smrčina, M.; Majer, P.; Mareš, M. Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis. J. Med. Chem. 2020, 63, 1576–1596. http://dx.doi.org/10.1021/acs.jmedchem.9b01351
• Hudeček, O.; Benoni, R.; Reyes-Gutierrez, P. E.; Culka, M.; Šanderová, H.; Hubálek, M.; Rulíšek, L.; Cvačka, J.; Krásný, L.; Cahová, H. Dinucleoside polyphosphates act as 5′-RNA caps in bacteria. Nat. Commun. 2020, 11, 1052. http://dx.doi.org/10.1038/s41467-020-14896-8
• Lux, V.; Brouns, T.; Čermáková, K.; Srb, P.; Fábry, M.; Mádlíková, M.; Hořejší, M.; Kukačka, Z.; Novák, P.; Kugler, M.; Brynda, J.; DeRijck, J.; Christ, F.; Debyser, Z.; Veverka, V. Molecular Mechanism of LEDGF/p75 Dimerization. Structure 2020, 28, 1288–1299.e7. http://dx.doi.org/10.1016/j.str.2020.08.012
• Began, J.; Cordier, B.; Březinová, J.; Delisle, J.; Hexnerová, R.; Srb, P.; Rampírová, P.; Kožíšek, M.; Baudet, M.; Couté, Y.; Galinier, A.; Veverka, V.; Doan, T.; Strisovsky, K. Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease. EMBO J. 2020, 39, e102935. http://dx.doi.org/10.15252/embj.201489367 
• Krafcikova, P.; Silhan, J.; Nencka, R.; Boura, E. Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin. Nat. Commun. 2020, 11, 3717. http://dx.doi.org/10.1038/s41467-020-17495-9

• Myšková, J.; Rybakova, O.; Brynda, J.; Khoroshyy, P.; Bondar, A.; Lazar, J. Directionality of light absorption and emission in representative fluorescent proteins. Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 32395–32401. http://dx.doi.org/10.1073/pnas.2017379117
• Barton, J.; Gulka, M.; Tarabek, J.; Mindarava, Y.; Wang, Z.; Schimer, J.; Raabova, H.; Bednar, J.; Plenio, M. B.; Jelezko, F.; Nesladek, M.; Cigler, P. Nanoscale Dynamic Readout of a Chemical Redox Process Using Radicals Coupled with Nitrogen-Vacancy Centers in Nanodiamonds. ACS Nano 2020, 14, 12938–12950. http://dx.doi.org/10.1021/acsnano.0c04010
• Buttersack, T.; Mason Philip, E.; McMullen Ryan, S.; Schewe, H. C.; Martinek, T.; Brezina, K.; Crhan, M.; Gomez, A.; Hein, D.; Wartner, G.; Seidel, R.; Ali, H.; Thürmer, S.; Marsalek, O.; Winter, B.; Bradforth Stephen, E.; Jungwirth, P. Photoelectron spectra of alkali metal–ammonia microjets: From blue electrolyte to bronze metal. Science 2020, 368, 1086–1091. http://dx.doi.org/10.1126/science.aaz7607
• Bím, D.; Chalupský, J.; Culka, M.; Solomon, E. I.; Rulíšek, L.; Srnec, M. Proton–Electron Transfer to the Active Site Is Essential for the Reaction Mechanism of Soluble 9-Desaturase. J. Am. Chem. Soc. 2020, 142, 10412–10423. http://dx.doi.org/10.1021/jacs.0c01786
• Wu, T.; Li, G.; Kapitán, J.; Kessler, J.; Xu, Y.; Bouř, P. Two Spectroscopies in One: Interference of Circular Dichroism and Raman Optical Activity. Angew. Chem. Int. Ed. 2020, 59, 21895–21898. http://dx.doi.org/10.1002/anie.202011146