IOCB Most Significant Publications 2019

The most significant publications in CHEM, BIO & PHYS clusters are selected annually by an external international panel of reviewers and the IOCB director.

The awarded publications are listed in their respective clusters alphabetically by title.

• Novotná, B.; Vaneková, L.; Zavřel, M.; Buděšínský, M.; Dejmek, M.; Smola, M.; Gutten, O.; Tehrani, Z. A.; Pimková Polidarová, M.; Brázdová, A.; Liboska, R.; Štěpánek, I.; Vavřina, Z.; Jandušík, T.; Nencka, R.; Rulíšek, L.; Bouřa, E.; Brynda, J.; Páv, O.; Birkuš, G. Enzymatic Preparation of 2′–5′,3′–5′-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations. J. Med. Chem. 2019, 62, 10676–10690. http://dx.doi.org/10.1021/acs.jmedchem.9b01062
• Grüner, B.; Brynda, J.; Das, V.; Šícha, V.; Štěpánková, J.; Nekvinda, J.; Holub, J.; Pospíšilová, K.; Fábry, M.; Pachl, P.; Král, V.; Kugler, M.; Mašek, V.; Medvedíková, M.; Matějková, S.; Nová, A.; Lišková, B.; Gurská, S.; Džubák, P.; Hajdúch, M.; Řezáčová, P. Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX. J. Med. Chem. 2019, 62, 9560–9575. http://dx.doi.org/10.1021/acs.jmedchem.9b00945
• Hernández-Guerra, D.; Hlavačková, A.; Pramthaisong, C.; Vespoli, I.; Pohl, R.; Slanina, T.; Jahn, U. Photochemical C−H Amination of Ethers and Geminal Difunctionalization Reactions in One Pot. Angew. Chem. Int. Ed. 2019, 58, 12440–12445. http://dx.doi.org/10.1002/anie.201905209
• Tenora, L.; Alt, J.; Dash, R. P.; Gadiano, A. J.; Novotná, K.; Veeravalli, V.; Lam, J.; Kirkpatrick, Q. R.; Lemberg, K. M.; Majer, P.; Rais, R.; Slusher, B. S. Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs. J. Med. Chem. 2019, 62, 3524–3538. http://dx.doi.org/10.1021/acs.jmedchem.8b02009

• Šimonová, A.; Svojanovská, B.; Trylčová, J.; Hubálek, M.; Moravčík, O.; Zavřel, M.; Pávová, M.; Hodek, J.; Weber, J.; Cvačka, J.; Pačes, J.; Cahová, H. LC/MS analysis and deep sequencing reveal the accurate RNA composition in the HIV-1 virion. Sci. Rep. 2019, 9, 8697. http://dx.doi.org/10.1038/s41598-019-45079-1
• Holubová, M.; Hrubá, L.; Popelová, A.; Bencze, M.; Pražienková, V.; Gengler, S.; Kratochvílová, H.; Haluzík, M.; Železná, B.; Kuneš, J.; Hölscher, C.; Maletínská, L. Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology. Neuropharmacology 2019, 144, 377–387. http://dx.doi.org/10.1016/j.neuropharm.2018.11.002
• Macháčková, K.; Mlčochová, K.; Potalitsyn, P.; Hanková, K.; Socha, O.; Buděšínský, M.; Muždalo, A.; Lepšík, M.; Černeková, M.; Radosavljević, J.; Fábry, M.; Mitrová, K.; Chrudinová, M.; Lin, J.; Yurenko, Y.; Hobza, P.; Selicharová, I.; Žáková, L.; Jiráček, J. Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. J. Biol. Chem. 2019, 294, 17371–17382. http://dx.doi.org/10.1074/jbc.RA119.010072
• Vaníková, Z.; Janoušková, M.; Kambová, M.; Krásný, L.; Hocek, M. Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA. Chem. Sci. 2019, 10, 3937–3942. http://dx.doi.org/10.1039/c9sc00205g

• Hellerstedt, J.; Cahlík, A.; Stetsovych, O.; Švec, M.; Shimizu, T. K.; Mutombo, P.; Klívar, J.; Stará, I. G.; Jelínek, P.; Starý, I. Aromatic Azide Transformation on the Ag(111) Surface Studied by Scanning Probe Microscopy. Angew. Chem. Int. Ed. 2019, 58, 2266–2271. http://dx.doi.org/10.1002/anie.201812334
• Jaroš, A.; Bonab, E. F.; Straka, M.; Foroutan-Nejad, C. Fullerene-Based Switching Molecular Diodes Controlled by Oriented External Electric Fields. J. Am. Chem. Soc. 2019, 141, 19644–19654. http://dx.doi.org/10.1021/jacs.9b07215
• Eyrilmez, S. M.; Köprülüoğlu, C.; Řezáč, J.; Hobza, P. Impressive Enrichment of Semiempirical Quantum Mechanics-Based Scoring Function: HSP90 Protein with 4541 Inhibitors and Decoys. ChemPhysChem 2019, 20, 2759–2766. http://dx.doi.org/10.1002/cphc.201900628
• Mason, P. E.; Jungwirth, P.; Duboué-Dijon, E. Quantifying the Strength of a Salt Bridge by Neutron Scattering and Molecular Dynamics. J. Phys. Chem. Lett. 2019, 10, 3254–3259. http://dx.doi.org/10.1021/acs.jpclett.9b01309
• Li, G.; Kessler, J.; Cheramy, J.; Wu, T.; Poopari, M. R.; Bouř, P.; Xu, Y. Transfer and Amplification of Chirality Within the “Ring of Fire” Observed in Resonance Raman Optical Activity Experiments. Angew. Chem. Int. Ed. 2019, 58, 16495–16498. http://dx.doi.org/10.1002/anie.201909603