![Dana Hocková Lecture – Hana Lísalová](/upload/files/b5/37/b53738049046b43c94d5d1cdfb5e26653f8565b9.jpg)
10 a.m. From antifouling (nano-)coatings to smart biosensing in complex media (Lecture Hall)
3 p.m. Career workshop "Being blond and pushing science forward" (Club)
Abstract
In tribute to a brilliant scientist Dana Hocková it is my honor to introduce our recent research on pushing the boundaries of antifouling bio-functional materials and nano-coatings, with a particular focus on enhancing biosensing in real-world media. To address this challenge, we explore the fascinating properties of ultrathin antifouling bio-functional polymer brushes. Namely, we will share recent advances in the following areas: i) design, fabrication, and responsive behavior of antifouling functionalizable brush nano-coatings, ii) molecular-level research on biofunctionalization, iii) the integration of zwitterionic brushes in advanced cell-on-a-chip systems, and iv) examples of antifouling point-of-care biosensors with tailor-made microfluidics systems. Results show how important (and challenging) it is to precisely control over the antifouling properties of polymer nano-coatings when submerged in real-world complex biological fluids. We detail new approaches to probe brushes with emerging electrochemical impedance spectroscopy technique. We present a new antifouling terpolymer brush with a superior combination of antifouling and bio-functionalization capabilities over similar bio-functional coatings. This material has been successfully employed in several antifouling biosensors; for example, in piezoelectric biosensors for the rapid sensitive detection of SARS-CoV-2 in complex clinical and surface swab samples as well as bacterial pathogens in fresh foods.
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/5f/d4/5fd4c0f920d35279d195880be1bb70dbbf7d95d9.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/9c/f4/9cf4fa938b1712115f3857c93cf418ac10e6e8ab.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/09/e7/09e7922d61dc9243b74d699827384611a9b06237.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/6b/dc/6bdc830c7d6c743a043b5577e78e588b8ac7cc58.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/77/3e/773e276d01958dba20ad7228f8995e5bc5f95f32.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/d7/1e/d71efb4886bf01292ab83316b59c59d07d5b2c67.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/22/44/2244e3c24a5127a2dafeb8473201ee79fe919a46.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/0a/9e/0a9e8ffd9a6c5747d3c1816dbfe5b7a13d499d0d.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/e0/ed/e0ed1733e16b5d35888d6c3c0850e61e9409b1a9.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/d9/97/d9970cad8a3269c23b73846dca74e2a32344d7ec.jpg)
![Photo: Tomáš Belloň / IOCB Prague](/upload/files/f6/8d/f68db958d40f8ccd429c90148d5d6faac9bc3661.jpg)