Prof. Scott Miller (Department of Chemistry, Yale University, New Haven, Connecticut, USA)
Searching for Selective Catalytic Reactions in Complex Molecular Environments
13 March 2018, 10 a.m.
IOCB Prague, Lecture Hall (Building A, 2nd floor, A2.01)
Abstract
This lecture will describe recent developments in our efforts to develop low-molecular weight catalysts for asymmetric reactions. Over time, our view of asymmetry has ebbed and flowed, with foci on enantioselectivity, site-selectivity and chemoselectivity. In most of our current work, we are studying issues of enantioselectivity as a prelude to extrapolation of catalysis concepts to more complex stereochemical settings where multiple issues are presented in a singular substrate. Moreover, we continuously examine an interplay between screening of catalyst libraries and more hypothesis-driven experiments that emerge from screening results. Some of the mechanistic paradigms, and their associated ambiguities, will figure strongly in the lecture.
