Invited Lecture – Paul Knochel

In the first part of the lecture, the preparation of highly functionalized organozinc compounds will be emphasized using zinc powder in the presence of LiCl.¹ This method allows the preparation of a range of heteroarylzinc species bearing a ketone or an aldehyde. In a second part, the preparation of polyfunctional magnesiated heterocycles using either a X/Mg- exchange triggered by i-PrMgCl-LiCl or by a direct deprotonation using new soluble Mg-bases such as TMPMgCl-LiCl or (TMP)2Mg-2LiCl.² Applications of these polyfunctional organometallics for the synthesis of bioactive molecules will be shown.³ Finally, the synthesis of aminated heterocycles using an oxidative amination procedure with chloranil will be described.⁴

1. Krasovskiy, A.; Gavryushin, A.; Malakhov, V.; Knochel, P. Angew. Chem. Int. Ed. 2006, 45, 6040. 
2. Boudet, N.; Knochel, P. Org. Lett. 2006, 8, 3737. 
3. Krasovskiy, A.; Krasovskaya, V.; Knochel, P. Angew. Chem. Int. Ed. 2006, 45, 2958. 
4. del Amo, V.; Dubbaka, S.; Krasovskiy, A.; Knochel, P. Angew. Chem. Int. Ed. 2006, 45, 7838.