Michal Česnek

All publications

Latest publications

Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine

A. Chayka M. Česnek E. Kužmová J. Kozák E. Tloušťová A. Dvořáková T. Strmeň B. Brož Z. Osifová M. Dračínský H. Mertlíková-Kaiserová Z. Janeba

Journal of Medicinal Chemistry 67 (12): 10135–10151 (2024)

Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir

P. Kraina M. Česnek E. Tloušťová H. Mertlíková-Kaiserová C. J. Fulton E. K. Davidson B. P. Smith V. J. Watts Z. Janeba

Bioorganic & Medicinal Chemistry 95: 117508 (2023)

Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases

T. Klejch D. T. Keough G. King E. Doleželová M. Česnek M. Buděšínský A. Zíková Z. Janeba L. W. Guddat D. Hocková

Journal of Medicinal Chemistry 65 (5): 4030–4057 (2022)

Halogen-Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases

M. Česnek M. Šafránek M. Dračínský E. Tloušťová H. Mertlíková-Kaiserová M. P. Hayes V. J. Watts Z. Janeba

ChemMedChem 17 (1): e202100568 (2022)