CS

Stancho Stanchev

mail stancho.stanchevinvalid-email-name@invalid-email-domainuochb.cas.cz
phone +420 220 183 479
Scientist
Kvido Stříšovský Group
Intramembrane Proteolysis and Biological Regulation
All publications

Latest publications

Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency
K. Bach J. Dohnálek J. Škerlová J. Kuzmík E. Poláchová S. Stanchev P. Majer J. Fanfrlík A. Pecina J. Řezáč M. Lepšík V. Borshchevskiy V. Polovinkin K. Stříšovský
European Journal of Medicinal Chemistry 275: 116606 (2024)
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Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy
E. Poláchová K. Bach E. Heuten S. Stanchev A. Tichá P. Lampe P. Majer T. Langer M. K. Lemberg K. Stříšovský
Journal of Medicinal Chemistry 66 (1): 251–265 (2023)
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Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria
S. Gandhi R. P. Baker S. Cho S. Stanchev K. Stříšovský S. Urban
Cell Chemical Biology 27 (11): 1410-1424 (2020)
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General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases
A. Tichá S. Stanchev K. R. Vinothkumar D. C. Mikles P. Pachl J. Began J. Škerle K. Švehlová M. T. N. Nguyen S. H. L. Verhelst D. C. Johnson D. A. Bachovchin M. Lepšík P. Majer K. Stříšovský
Cell Chemical Biology 24 (12): 1523-1536 (2017)
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