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SCIENTIFIC CV
since 2016: Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Targeted analogues of nucleic acid components, head of the senior research group
since 2919: University of Chemistry and Technology, Prague
2010 – 2015: Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, head of the junior research group
2008 – 2010: Institute of Organic Chemistry and Biochemistry, AS CR (team of Prof. A. Holý)
2005 – 2008: Moravek Biochemicals, Inc, Brea, California, USA, research scientist in industry
EDUCATION AND PROFESSIONAL EXPERIENCE:
2004 – 2005: post-doctoral stay, Northern Arizona University, Flagstaff, Arizona, (Paul F. Torrance)
2001 – 2004: post-doctoral stay, Brigham Young University, Provo, Utah (Prof. Morris J. Robins)
1995 – 2001: Ph.D. study, Institute of Organic Chemistry and Biochemistry (supervisor Prof. A. Holý)
1989 – 1995: M. S. degree (Ing.) organic chemistry, Institute of Chemical Technology, Prague
RESEARCH PROFILE: Interest in heterocyclic chemistry, molecular photoswitches, chemistry of nucleic acids components, purine and pyrimidine chemistry, acyclic nucleoside phosphonates, SAR studies. Expertise cover areas of organic and medicinal chemistry, drug design and development, antiviral, anticancer, anti-parasitic, and anti-inflammatory agents. Collaborations worldwide – Gilead Sciences, Inc. (USA), Queensland University (Australia), Rega Institute for Medical Research (Belgium), Purdue University (USA), Massachusetts Institute of Technology – MIT (USA), Weizmann Institute of Science (Israel). Supervision experience: 15 students (Ph.D., Ms, Bc,). Regular reviewer for international journals (Bioorg. Med. Chem., Eur. J. Med. Chem., Org. Lett., Med. Chem. Rev., Arkivoc, ChemMedChem, etc.). Associate editor of Antiviral Chemistry & Chemotherapy (SAGE journals).
MEMBERSHIP/ACTIVITY: (a) International Society for Antiviral Research (ISAR) – Since 2022 a member of ISAR Board of Directors; (b) International Society of Nucleosides, Nucleotides & Nucleic Acids; (c) International Society of Heterocyclic Chemistry (ISHC); (d) American Chemical Society. Member of the Board of the Intitute (2012 – 2016) and vice-chairman of Supervisory Board of IOCB (since 2017). Member of Doctoral Study Board at UCT Prague (since 2023).
PUBLICATION RECORD, PRESENTATIONS: author of 118 papers with over 1600 citations, 1250 without self-citations (WOS, 9/2024), H-index 23, presented research at over 50 conferences and webinars, 25 invited lectures, patents (EP2860185-A1, WO2015051874-A1, EP 13004845, US 08466275, CZ201100026-A3, WO2012116666-A1, US 07572909).
AWARD: Petr Sedmera Award 2016 (collective award)
Invited Scientist: University of Cagliary, Italy, 1-7 May, 2023
RECENT SCIENTIFIC ACTIVITY: TEACHING: Charles University (since 2017) – Seminar from Medicinal Chemistry; The University of Chemistry and Technology (since 2019) – Medicinal Chemistry (course for Ph.D. students). REVIEWING BOARDS: reviewer for European Science Foundation (since 2019) and for the Grant Agency of Charles University (since 2021). SELECTED INVITED LECTURES: 4th International Caparica Christmas Conference on Translational Chemistry (IC3TC), Portugal, 2021, Endeavor International Webinar on Chemistry, online, 2021, Keynote lecture; 3rd International Caparica Christmas Conference on Translational Chemistry (IC3TC), Portugal, 2019; 6th Prague-Weizmann Summer School. Advances in Drug Discovery, Prague, 2019; Joint Meeting on Medicinal Chemistry (JMMC), Prague, 2019; Johns Hopkins Drug Discovery, JHU, Baltimore, USA, 2019; Brigham Young University, Provo, USA, 2019; Utah State University, Logan, USA, 2019; Innovative Approaches for Identification of Antiviral Agents Summer School (4th IAAASS), Pula, Italy, 2018; 33-CLAQ & Quimicuba, Havana, Cuba, 2018; Drug Discovery Chemistry, San Diego, USA, 2022; CLAQ 2022, Rio de Janeiro, Brazil, 2022; ICAR 2023, Lyon, France, 2023.