IOCB covers 2025
Here are some of the front/back/inside covers created to accompany and illustrate scientific articles authored by IOCB researchers and published in 2025.
The mysterious world of non-canonical caps – What we know and why we need new sequencing techniques
Dive into the intriguing world of 5’ non-canonical RNA caps —unique modifications derived from metabolites and cofactors such as NAD, FAD, CoA, UDP-glucose, UDP-N-acetylglucosamine, and dinucleoside polyphosphates—that challenge the long-held belief that RNA is capped solely by N7-methylguanosine. This review 10.1002/cbic.202400604 by Flaminia Mancini and Hana Cahova highlights how cutting-edge techniques like LC-MS have uncovered these caps across all domains of life and evaluates existing sequencing methods, emphasizing the urgent need for innovative technologies to decipher their biological roles. Discover a rapidly evolving field that could reshape our understanding of RNA biology.
- Article: Mancini, F.; Cahova, H. The Mysterious World of Non-Canonical Caps – What We Know and Why We Need New Sequencing Techniques. ChemBioChem 2025, 26 (3), e202400604. https://doi.org/10.1002/cbic.202400604
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3’-dehydroxypurpurogallin-4-carboxamides as influenza A endonuclease inhibitors: synthesis, structure-activity relationship analysis, and structural characterization of protein complex
The image shows a scene where the mushroom motif is linked to the chemical formulas of purpurogallin derivatives – colchicine, fomenanthriol, and aurantricholone – natural pigments in mushroom caps. These compounds appear as orange, red, or brown dyes, echoing the mushrooms’ colors. It also represents the mushroom season, popular in Europe during autumn. A blue “shield” symbolizes the protective effect of our developed purpurogallines, which block influenza endonuclease, depicted as scissors ready to cleave RNA. (Cover art: Tomáš Belloň/IOCB Prague)
- Article: Mancini, F.; Cahova, H. The Mysterious World of Non-Canonical Caps – What We Know and Why We Need New Sequencing Techniques. ChemBioChem 2025, 26 (3), e202400604. https://doi.org/10.1002/cbic.202400604
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From boom to bloom: synthesis of diazidodifluoromethane, its stability and applicability in the ‘click’ reaction
Cover art: Tomáš Belloň/IOCB Prague
- Article: Ziabko, M.; Suikov, S.; Filgas, J.; Slavíček, P.; Gazdurová, M.; Bednárová, L.; Matyáš, R.; Klepetářová, B.; David, T.; Beier, P. From boom to bloom: synthesis of diazidodifluoromethane, its stability and applicability in the ‘click’ reaction. Chem. Commun. 2025, 61, 885–888. https://doi.org/10.1039/D4CC05128A
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