IOCB covers 2024

Hébra et al. introduce POMBOX, a molecular cloning (MoClo) toolbox for the fission yeast Schizosaccharomyces pombe, a popular model organism in molecular biology. POMBOX is compatible with established Golden Gate MoClo toolkits for budding yeast and other organisms, allowing for easy exchange and reuse of genetic parts. (Cover art: Tomáš Belloň / IOCB Prague)

• Article: Hebra, T.; Smrčková, H.; Elkatmis, B.; Převorovský, M.; Pluskal, T. POMBOX: A Fission Yeast Cloning Toolkit for Molecular and Synthetic Biology. ACS Synth. Biol. 2024, 13, 558–567. https://doi.org/10.1021/acssynbio.3c00529
  
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Artistic view of our experimental conditions: a liquid jet is generated from a cryogenic nozzle setup into a vacuum while naphthalene molecules evaporate from the jet.

• Article: Nemirovich, T.; Young, B.; Brezina, K.; Mason, P. E.; Seidel, R.; Stemer, D.; Winter, B.; Jungwirth, P.; Bradforth, S. E.; Schewe, H. C. Stability and Reactivity of Aromatic Radical Anions in Solution with Relevance to Birch Reduction. J. Am. Chem. Soc. 2024, 146, 8043–8057. https://doi.org/10.1021/jacs.3c11655 
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Cover art: Lucie Wohlrábová / IOCB Prague

• Article: Copko J., Slanina T. Multiplicity-driven photochromism controls three-state fulgimide photoswitches. Chem. Commun. 2024. https://doi.org/10.1039/d3cc05975h
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Illustrative representation of the brain in which intense neurotransmitter excitations occur, represented by colored discharges. This cover art is intended to highlight our metabolomic and lipidomic study of GCPII-deficient mouse models, where it is the disruption of NAAG concentrations that affects the brain lipidome and metabolome. The cover art was generated using DALL·E 3.

• Article: Sedlák, F.; Kvasnička, A.; Marešová, B.; Brumarová, R.; Dobešová, D.; Dostálová, K.; Šrámková, K.; Pehr, M.; Šácha, P.; Friedecký, D.; Konvalinka, J. Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition. ACS Chem. Neurosci. 2024, 15, 1342–1355. https://doi.org/10.1021/acschemneuro.3c00494
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Featured on the cover is a representation of advanced cross-linked gelatin-based hydrogels engineered for elevated radiodensity, enabling real-time tracking of material development in living organisms through radioimaging. These hydrogels stand as a versatile and adjustable platform, allowing for the tunability of mechanical properties, swelling, and rates of biodegradation. Noteworthy for their cell-interactivity, biocompatibility, and biodegradability, these materials signify a leap forward in bioengineering innovation, specifically within the field of tissue engineering. (Cover art: Tomáš Belloň / IOCB Prague)

• Article: Groborz, O.; Kolouchova, K.; Parmentier, L.; Szabó, A.; Van Durme, B.; Dunlop, D.; Slanina, T.; Van Vlierberghe, S. Photoprintable Radiopaque Hydrogels for Regenerative Medicine. ACS Appl. Eng. Mater. 2024, 2, 811–817. https://doi.org/10.1021/acsaenm.3c00533
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An elusive T-shaped high-valent Cu^III derivative, Cu(CF₃)₃ which is depicted on the cover, was stabilized in the form of solvates and theoretically studied. In their Research Article, V. Motornov, X. Ribas, P. Beier, and co-workers report the synthesis of solvates Cu(CF₃)₃⋅2DMF and Cu(CF₃)₃⋅MeCN, which were fully characterized including X-ray crystallography. Ligand substitution in these solvates enables access to a variety of new high-valent Cu^III complexes. (Cover art: Tomáš Belloň / IOCB Prague)

• Article: Motornov, V.; Procházka, M.; Alpuente, N.; Salvador, P.; Slavíček, P.; Klepetářová, B.; Ribas, X.; Beier, P. Introducing Weakly Ligated Tris(trifluoromethyl)copper(III). ChemistryEurope 2024, 2, e202400004. https://doi.org/10.1002/ceur.202400004
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