Structural studies of histone chaperones
Structural Biology
Abstract
Histone chaperones play an important role in chromatin remodeling. Intrinsically disordered histone chaperones can transition from an unstructured to a structured state upon binding to histones. This type of molecule plays a key role in maintaining chromatin structure and dynamics, DNA replication, transcription and repair. Their deregulation is associated with various diseases, including cancer, underscoring their importance for normal cellular function. The aim of the project will be to study the molecular basis of histone recognition by chaperones, with emphasis on unraveling the role of unstructured regions on the function of these molecules using structural biology techniques (cryo-electron microscopy, NMR spectroscopy or X-ray crystallography).
Field of study: Structural biology
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
University partners
How to apply
If you are interested, please contact the supervisor: vaclav.veverka@uochb.cas.cz