A study from scientists led by Lenka Maletínská from IOCB Prague broadened our understanding of metabolic disorders related to neuropeptide FF receptor 2 (NPFFR2) deficiency.
NPFFR2 is a receptor with a possible function in pain modulation and regulation of the opioid system. Previous studies on NPFFR2-deficient mice also revealed its involvement in energy balance and thermogenesis.
The recent study showed that male and female NPFFR2 knockout (KO) mice, fed standard or high-fat diets, exhibit severe glucose intolerance. NPFFR2 KO male mice had lower body weights, reduced adipose tissues, liver size, and plasma leptin levels on a high-fat diet. On the other hand, NPFFR2 deletion in female mice inhibited adipose tissue lipolysis.
The findings shed light on the metabolic impact of NPFFR2 deficiency, contributing to our understanding of energy regulation and potential therapeutic targets for metabolic disorders.
Read the article: Karnošová, A., Strnadová, V., Železná, B., Kuneš, J., Kašpárek, P., & Maletínská, L. NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose. Clin. Sci. 2023, 137, 847–862. https://doi.org/10.1042/cs20220880
