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The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase
European Journal of Pharmaceutical Sciences 205: 106990 (2025)
The PB2 subunit of the influenza virus polymerase complex is essential for viral replication, primarily through a mechanism known as cap-snatching. In this process, PB2 binds to the 5’ cap structure of host pre-mRNAs, enabling the viral polymerase to hijack the host transcriptional machinery. This binding facilitates the cleavage and integration of the capped RNA fragment into viral mRNA, thereby promoting efficient viral replication. Inhibiting the PB2-cap interaction is therefore crucial, as it directly disrupts the viral replication cycle. Consequently, targeting PB2 with specific inhibitors is a promising strategy for antiviral drug development against influenza. However, there are currently no available methods for the high-throughput screening of potential inhibitors. The development of new inhibitor screening methods of potential PB2 binders is the focus of this study.In this study, we present two novel methods, DIANA and AlphaScreen, for screening influenza PB2 cap-binding…
MassSpecGym: A benchmark for the discovery and identification of molecules
Conference on Neural Information Processing Systems (NeurIPS) 38: 1-31 (2024)
New insights into the mechanisms and prevention of central nervous system oxygen toxicity: A prospective review
Life Sciences 360: 123169 (2025)
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery
Journal of Biological Chemistry 2025: Early View